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Mele0/README.md

Hi there, I'm Alex

I'm currently a PhD researcher in Artificial Intelligence and Machine Learning in Biomedicine at Imperial College London. My research focuses on deep learning, continuous-time modelling, uncertainty quantification, and machine learning for longitudinal biomedical data. Previously, I was a Machine Learning Researcher at Stanford University, where I developed and evaluated machine learning models on large-scale biomedical cohorts.

📚 Research

I've worked on several machine learning and biomedical research projects, including:

🤗 HuggingFace Projects

I've developed a dataset for stress-testing robustness on longitudinal and population-scale biomedical models:

  • SynLV — A synthetic benchmark for studying decision-time incompleteness in longitudinal survival prediction, with controllable longitudinal dynamics, observation processes, and missingness mechanisms.

💻 GitHub Projects

I've worked on several machine learning and biomedical data science projects featured on GitHub, including:

  • Polybitrage – Built a low-latency arbitrage engine for Polymarket and Kalshi, targeting cross-market pricing inefficiencies. Implemented N-leg arbitrage detection, depth-aware position sizing, and latency-sensitive execution with fill-or-kill orders and risk limits. Achieved sub-100 µs scan latency using Python, Rust, and Cython, with end-to-end latency monitoring via Prometheus/Grafana.

  • COUGHVID - Deep learning models for detecting upper respiratory tract infections from cough audio. Uses mel-spectrogram representations with CNN and LSTM architectures, with a focus on robustness to background noise and recording-device variability.

  • CKD Patient Profiling - Proteomics-based patient profiling pipeline for chronic kidney disease. Uses UMAP and Gaussian Mixture Models for clustering, Random Forest and LASSO for feature selection, and survival analysis for clinical outcome modelling.

  • Phenotype Prediction - Machine learning pipeline for high-dimensional phenotype prediction using UK Biobank data. Includes XGBoost, LightGBM, CatBoost, feature selection, and SHAP-based model interpretation.

  • ACDS - Attitude Control and Determination System for a CubeSat, in portable C. Implements B-dot magnetorquer detumbling and a 3-axis quaternion PID pointing controller, with IGRF-13 geomagnetic-field and SGP4 orbit-propagation models for attitude determination.

Pinned Loading

  1. SynLV SynLV Public

    Public code artifact for SynLV, a synthetic benchmark for decision-time incompleteness in longitudinal survival prediction.

    Python

  2. Polybitrage Polybitrage Public

    High-frequency trading engine for prediction markets.

    Python

  3. EPC EPC Public

    Code and data for "EPC Mirage": how grid decarbonisation can overstate retrofit progress in carbon-weighted building energy ratings — England & Wales non-domestic EPCs, a European rating-scheme typ…

    Python

  4. Phenotype_Prediction Phenotype_Prediction Public

    Toolkit for predicting human phenotypes from UK Biobank.

    Python

  5. COUGHVID COUGHVID Public

    Deep learning models for detecting upper respiratory tract infections using the COUGHVID cough audio dataset. Includes CNN and LSTM architectures trained on mel-spectrograms with spectral augmentat…

    Jupyter Notebook 1

  6. ACDS ACDS Public

    Attitude Control and Determination System (ACDS) for a CubeSat: B-dot detumbling and 3-axis quaternion PID pointing, with IGRF-13 geomagnetic and SGP4 orbit models.

    C