Skip to content

docs(init): pass Human-GEM's spontaneous reactions to prep_init_model - #86

Merged
edkerk merged 2 commits into
mainfrom
human-gem-spontaneous
Oct 17, 2026
Merged

edkerk merged 2 commits into
mainfrom
human-gem-spontaneous

Conversation

@edkerk

@edkerk edkerk commented Sep 25, 2026 •

Copy link
Copy Markdown
Collaborator
  • The Python example for preparing Human-GEM reads the spontaneous column of reactions.tsv and passes it to prep_init_model, as the MATLAB example does.
  • A note explains why: ftINIT keeps spontaneous reactions in every extracted model. In Human-GEM these include diffusion transports (cytosol–nucleus, and gases and water across membranes; feat: flag diffusion transports as spontaneous so ftINIT keeps them SysBioChalmers/Human-GEM#1101). Without them, ftINIT can drop such transports in some samples and create artefacts such as DCK becoming essential.
  • prepHumanModelForftINIT is described as needing Human-GEM 2.0.1 or later.

@edkerk
edkerk merged commit e3feefe into main Oct 17, 2026
2 checks passed
@edkerk
edkerk deleted the human-gem-spontaneous branch October 17, 2026 21:36
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment

Labels

None yet

Projects

None yet

Development

Successfully merging this pull request may close these issues.

1 participant