diff --git a/graalpython/com.oracle.graal.python.test/src/tests/test_graalpy_opts.py b/graalpython/com.oracle.graal.python.test/src/tests/test_graalpy_opts.py
new file mode 100644
index 0000000000..599005d4b1
--- /dev/null
+++ b/graalpython/com.oracle.graal.python.test/src/tests/test_graalpy_opts.py
@@ -0,0 +1,324 @@
+# Copyright (c) 2022, 2026, Oracle and/or its affiliates. All rights reserved.
+# DO NOT ALTER OR REMOVE COPYRIGHT NOTICES OR THIS FILE HEADER.
+#
+# The Universal Permissive License (UPL), Version 1.0
+#
+# Subject to the condition set forth below, permission is hereby granted to any
+# person obtaining a copy of this software, associated documentation and/or
+# data (collectively the "Software"), free of charge and under any and all
+# copyright rights in the Software, and any and all patent rights owned or
+# freely licensable by each licensor hereunder covering either (i) the
+# unmodified Software as contributed to or provided by such licensor, or (ii)
+# the Larger Works (as defined below), to deal in both
+#
+# (a) the Software, and
+#
+# (b) any piece of software and/or hardware listed in the lrgrwrks.txt file if
+# one is included with the Software each a "Larger Work" to which the Software
+# is contributed by such licensors),
+#
+# without restriction, including without limitation the rights to copy, create
+# derivative works of, display, perform, and distribute the Software and make,
+# use, sell, offer for sale, import, export, have made, and have sold the
+# Software and the Larger Work(s), and to sublicense the foregoing rights on
+# either these or other terms.
+#
+# This license is subject to the following condition:
+#
+# The above copyright notice and either this complete permission notice or at a
+# minimum a reference to the UPL must be included in all copies or substantial
+# portions of the Software.
+#
+# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+# AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+# OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+# SOFTWARE.
+
+import sys
+import unittest
+
+if sys.implementation.name == "graalpy" and not __graalpython__.is_forced_uncached_interpreter:
+
+    skipUnlessSingleContext = unittest.skipUnless(__graalpython__.is_single_context, "requires single-context mode")
+
+    def assert_contains_bytecode(fun, bytecode_str):
+        bytecode = __graalpython__.dis(fun)
+        assert bytecode_str in __graalpython__.dis(fun), bytecode
+
+
+    def test_read_name_quickening_local():
+        code = compile("value = 42\nassert value == 42", "<test>", "exec")
+        for _ in range(5):
+            exec(code)
+        assert_contains_bytecode(code, "ReadName$LocalFastPath")
+
+
+    def test_read_global_quickening_builtin():
+        def tester():
+            return len((1, 2, 3))
+
+        for _ in range(5):
+            assert tester() == 3
+        assert_contains_bytecode(tester, "ReadGlobal$ReadBuiltinFastPath")
+
+
+    def test_read_global_quickening_global():
+        def tester():
+            return sys
+
+        for _ in range(5):
+            assert tester() is sys
+        assert_contains_bytecode(tester, "ReadGlobal$ReadGlobalFastPath")
+
+
+    def test_get_attr_quickening_module():
+        def tester(s):
+            return s.modules
+
+        for i in range(5):
+            tester(sys)
+        assert_contains_bytecode(tester, "GetAttribute$Module")
+
+
+    @skipUnlessSingleContext
+    def test_get_attr_quickening_module_int():
+        def tester_i(s):
+            return s.maxsize - 5
+
+        for i in range(5):
+            tester_i(sys)
+
+        __graalpython__.tdebug(33)
+        tester_i(sys)
+        assert_contains_bytecode(tester_i, "GetAttribute$Module$int")
+
+
+    def test_get_attr_quickening_type():
+        class K:
+            MY_ATTR = 'forty-two'
+
+        def tester(o):
+            return o.MY_ATTR
+
+        for i in range(5):
+            assert tester(K) == 'forty-two'
+        assert_contains_bytecode(tester, "GetAttribute$Type")
+
+
+    @skipUnlessSingleContext
+    def test_get_attr_quickening_type_int():
+        class Q:
+            MY_ATTR = 42
+
+        def tester(o):
+            return o.MY_ATTR - 2 + 2
+
+        for i in range(5):
+            assert tester(Q) == 42
+        assert_contains_bytecode(tester, "GetAttribute$Type$int")
+
+
+    def test_get_method_str_quickening():
+        def tester(s):
+            return s.rstrip()
+
+        for i in range(5):
+            assert tester('hello ') == 'hello'
+        assert_contains_bytecode(tester, "GetMethod$StringFastPath")
+
+
+    def test_get_method_builtin_quickening():
+        def tester(d):
+            return d.popitem()
+
+        d = {i:i for i in reversed(range(5))}
+        for i in range(5):
+            assert tester(d)[0] == i
+        assert_contains_bytecode(tester, "GetMethod$FastPath")
+
+
+    @skipUnlessSingleContext
+    def test_call_nilary_method_quickening_python_function():
+        def callee():
+            return 42
+
+        def tester():
+            return callee()
+
+        for _ in range(5):
+            assert tester() == 42
+        assert_contains_bytecode(tester, "CallNilaryMethod$CallPFunction")
+
+
+    @skipUnlessSingleContext
+    def test_call_unary_method_quickening_python_function():
+        def callee(a):
+            return a
+
+        def tester():
+            return callee(42)
+
+        for _ in range(5):
+            assert tester() == 42
+        assert_contains_bytecode(tester, "CallUnaryMethod$CallPFunction")
+
+
+    @skipUnlessSingleContext
+    def test_call_binary_method_quickening_python_function():
+        def callee(a, b):
+            return a + b
+
+        def tester():
+            return callee(40, 2)
+
+        for _ in range(5):
+            assert tester() == 42
+        assert_contains_bytecode(tester, "CallBinaryMethod$CallPFunction")
+
+
+    @skipUnlessSingleContext
+    def test_call_ternary_method_quickening_python_function():
+        def callee(a, b, c):
+            return a + b + c
+
+        def tester():
+            return callee(39, 2, 1)
+
+        for _ in range(5):
+            assert tester() == 42
+        assert_contains_bytecode(tester, "CallTernaryMethod$CallPFunction")
+
+
+    @skipUnlessSingleContext
+    def test_call_quaternary_method_quickening_python_function():
+        def callee(a, b, c, d):
+            return a + b + c + d
+
+        def tester():
+            return callee(36, 3, 2, 1)
+
+        for _ in range(5):
+            assert tester() == 42
+        assert_contains_bytecode(tester, "CallQuaternaryMethod$CallPFunction")
+
+
+    @skipUnlessSingleContext
+    def test_call_unary_method_quickening_builtin_method():
+        def tester(s):
+            return s.rstrip()
+
+        for _ in range(5):
+            assert tester("hello ") == "hello"
+        assert_contains_bytecode(tester, "CallUnaryMethod$CallObjectSingle")
+
+
+    @skipUnlessSingleContext
+    def test_call_binary_method_quickening_builtin_method():
+        def tester(s):
+            return s.startswith("hello")
+
+        for _ in range(5):
+            assert tester("hello world")
+        assert_contains_bytecode(tester, "CallBinaryMethod$CallObjectSingleContext")
+
+
+    @skipUnlessSingleContext
+    def test_call_ternary_method_quickening_builtin_method():
+        def tester(s):
+            return s.replace("world", "there")
+
+        for _ in range(5):
+            assert tester("hello world") == "hello there"
+        assert_contains_bytecode(tester, "CallTernaryMethod$BuiltinFunctionCached")
+
+
+    @skipUnlessSingleContext
+    def test_call_quaternary_method_quickening_builtin_method():
+        def tester(s):
+            return s.replace("l", "x", 1)
+
+        for _ in range(5):
+            assert tester("hello") == "hexlo"
+        assert_contains_bytecode(tester, "CallQuaternaryMethod$CallSingle")
+
+
+    @skipUnlessSingleContext
+    def test_get_attr_quickening_instance():
+        class K:
+            def __init__(self):
+                self.attr = 42
+
+        def tester(o):
+            return o.attr
+
+        for i in range(5):
+            assert tester(K()) == 42
+        assert_contains_bytecode(tester, "GetAttribute$InstanceValue")
+
+
+    @skipUnlessSingleContext
+    def test_get_attr_quickening_instance_int():
+        class K2:
+            def __init__(self):
+                self.attr2 = 37
+
+        def tester(o):
+            return o.attr2 + 5
+
+        for i in range(5):
+            assert tester(K2()) == 42
+        assert_contains_bytecode(tester, "GetAttribute$InstanceValue$int")
+
+
+    @skipUnlessSingleContext
+    def test_set_attr_quickening():
+        class K:
+            def __init__(self):
+                self.attr = 1
+
+        def tester(o, i):
+            o.attr = i
+
+        o = K()
+        for i in range(5):
+            tester(o, i)
+        assert o.attr == 4
+        assert_contains_bytecode(tester, "SetAttribute$InstanceValue")
+
+
+    @skipUnlessSingleContext
+    def test_get_method_python_class_quickening():
+        class K:
+            def foo(self):
+                return 'bar'
+
+        def tester(o):
+            return o.foo()
+
+        for i in range(5):
+            assert tester(K()) == 'bar'
+        assert_contains_bytecode(tester, "GetMethod$FastPath")
+
+
+    @skipUnlessSingleContext
+    def test_get_method_builtin_and_pyclass_quickening():
+        class MyDict:
+            def popitem(self):
+                return 42
+
+        def tester(d):
+            return d.popitem()
+
+        d = {i:i for i in reversed(range(5))}
+        for i in range(5):
+            assert tester(d)[0] == i
+            assert tester(MyDict()) == 42
+
+        assert_contains_bytecode(tester, "GetMethod$FastPath")
+
+
+if __name__ == '__main__':
+    unittest.main()
diff --git a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/builtins/modules/GraalPythonModuleBuiltins.java b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/builtins/modules/GraalPythonModuleBuiltins.java
index 87432f0c81..708f28d171 100644
--- a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/builtins/modules/GraalPythonModuleBuiltins.java
+++ b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/builtins/modules/GraalPythonModuleBuiltins.java
@@ -308,6 +308,7 @@ public void postInitialize(Python3Core core) {
             mod.setAttribute(tsLiteral("foreign_wrapper"), PNone.NO_VALUE);
         } else {
             mod.setAttribute(tsLiteral("interop_has_gil"), new InteropGilTester());
+            mod.setAttribute(tsLiteral("is_single_context"), language.isSingleContext());
         }
         addBuiltinConstant("using_native_primitive_storage_strategy", context.getLanguage().getEngineOption(PythonOptions.UseNativePrimitiveStorageStrategy));
         if (PythonImageBuildOptions.WITHOUT_PLATFORM_ACCESS || !context.getOption(PythonOptions.RunViaLauncher)) {
diff --git a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/attributes/LookupAttributeInMRONode.java b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/attributes/LookupAttributeInMRONode.java
index d43fe87a89..02c5e58add 100644
--- a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/attributes/LookupAttributeInMRONode.java
+++ b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/attributes/LookupAttributeInMRONode.java
@@ -322,7 +322,7 @@ public final Object execute(Node inliningTarget, Object klass, TruffleString key
         @Specialization
         static Object lookupPBCTCached(Node inliningTarget, PythonBuiltinClassType klass, TruffleString key,
                         @Bind PythonContext context,
-                        @Cached("findAttr(context, klass, key)") Object cachedValue) {
+                        @Cached(value = "findAttr(context, klass, key)", weak = true) Object cachedValue) {
             return cachedValue;
         }
 
diff --git a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/bytecode_dsl/PBytecodeDSLRootNode.java b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/bytecode_dsl/PBytecodeDSLRootNode.java
index 223dd6f753..0d6b5594ca 100644
--- a/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/bytecode_dsl/PBytecodeDSLRootNode.java
+++ b/graalpython/com.oracle.graal.python/src/com/oracle/graal/python/nodes/bytecode_dsl/PBytecodeDSLRootNode.java
@@ -1950,7 +1950,7 @@ public static Object doFastPath(VirtualFrame frame,
                         TruffleString name, PythonObject obj,
                         @Bind Node inliningTarget,
                         @Cached("obj.getShape()") Shape cachedShape,
-                        @Cached(value = "getManagedClassOrNull(cachedShape)", weak = true) PythonManagedClass managedClass,
+                        @Cached("getManagedClassOrNull(cachedShape)") PythonManagedClass managedClass,
                         @Cached("getPropertyGetterWithFinalAssumption(cachedShape, name)") PropertyGetter cachedPropertyGetter,
                         @Cached InlineWeakValueProfile slotsValueProfile,
                         @Cached InlinedBranchProfile hasInstanceValueBranchProfile,