diff --git a/README.md b/README.md
index 51a682af..12371f1a 100644
--- a/README.md
+++ b/README.md
@@ -131,7 +131,7 @@ For syntax, see [lookup.json](./lib/lookup.json), the available attributes are:
 "head": true                 Use the head of the default branch
 "prefix": "v"                Specify the prefix used in the module version.
 "flaky": true                Ignore failures
-"skip": true                 Completely skip the module
+"skip": true                 Completely skip the module. May also be a condition (platform, arch, distro, semver range, or an array/object of these, eg "win32" or ["aix", ">=24"]) to skip only when it matches
 "expectFail"                 Expect the module to fail, error if it passes
 "repo": "https://github.com/pugjs/jade" - Use a different github repo
 "stripAnsi": true            Strip ansi data from output stream of npm
@@ -140,6 +140,8 @@ For syntax, see [lookup.json](./lib/lookup.json), the available attributes are:
 "install": ["install", "--param1", "--param2"] - Array of command line parameters passed to `npm` or `yarn` or `pnpm` as install arguments
 "maintainers": ["user1", "user2"] - List of module maintainers to be contacted with issues
 "scripts": ["script1", "script2"] - List of scripts from package.json to run instead of 'test'
+                             An entry may also be an object, eg `{ "script": "script2", "skip": "win32" }`,
+                             where the optional "skip" takes the same values as the top-level "skip"; if every entry is skipped, use the top-level "skip" instead
 "tags": ["tag1", "tag2"]     Specify which tags apply to the module
 "useGitClone": true          Use a shallow git clone instead of downloading the module
 "submodules": ["path/to/submodule"]  Initialize only the listed submodules when using a git clone
diff --git a/lib/lookup.js b/lib/lookup.js
index 94434888..0a608b2a 100644
--- a/lib/lookup.js
+++ b/lib/lookup.js
@@ -176,7 +176,29 @@ export function lookup(context) {
           `${context.module.name} lookup-scripts`,
           rep.scripts
         );
-        context.module.scripts = rep.scripts;
+        const scripts = rep.scripts
+          .map((script) => {
+            if (typeof script === 'string') {
+              return script;
+            }
+            if (
+              !script ||
+              typeof script !== 'object' ||
+              typeof script.script !== 'string'
+            ) {
+              throw new TypeError(
+                `${detail.name}: each "scripts" entry must be a string or an object with a string "script" property`
+              );
+            }
+            return defaultMatcher.isMatch(script.skip) ? null : script.script;
+          })
+          .filter((script) => script !== null);
+        if (scripts.length === 0) {
+          throw new Error(
+            `${detail.name}: every "scripts" entry is skipped; use the top-level "skip" instead`
+          );
+        }
+        context.module.scripts = scripts;
       }
       if (rep.tags) {
         context.module.tags = rep.tags;
diff --git a/lib/lookup.json b/lib/lookup.json
index 906c2c85..d4a97032 100644
--- a/lib/lookup.json
+++ b/lib/lookup.json
@@ -329,7 +329,7 @@
   "resolve": {
     "prefix": "v",
     "maintainers": "ljharb",
-    "scripts": ["tests-only", "posttest"]
+    "scripts": ["tests-only", { "script": "posttest", "skip": "win32" }]
   },
   "rewire": {
     "prefix": "v",
diff --git a/test/fixtures/custom-lookup-scripts-skip-all.json b/test/fixtures/custom-lookup-scripts-skip-all.json
new file mode 100644
index 00000000..af89ca4f
--- /dev/null
+++ b/test/fixtures/custom-lookup-scripts-skip-all.json
@@ -0,0 +1,6 @@
+{
+  "omg-i-pass-with-scripts": {
+    "prefix": "v",
+    "scripts": [{ "script": "test", "skip": true }]
+  }
+}
diff --git a/test/fixtures/custom-lookup-scripts-skip-invalid.json b/test/fixtures/custom-lookup-scripts-skip-invalid.json
new file mode 100644
index 00000000..81b887ff
--- /dev/null
+++ b/test/fixtures/custom-lookup-scripts-skip-invalid.json
@@ -0,0 +1,6 @@
+{
+  "omg-i-pass-with-scripts": {
+    "prefix": "v",
+    "scripts": ["test", { "skip": "win32" }]
+  }
+}
diff --git a/test/fixtures/custom-lookup-scripts-skip.json b/test/fixtures/custom-lookup-scripts-skip.json
new file mode 100644
index 00000000..9764a83e
--- /dev/null
+++ b/test/fixtures/custom-lookup-scripts-skip.json
@@ -0,0 +1,12 @@
+{
+  "omg-i-pass-with-scripts": {
+    "prefix": "v",
+    "scripts": [
+      "test-build",
+      { "script": "test" },
+      { "script": "test-skipped", "skip": true },
+      { "script": "test-not-skipped", "skip": false },
+      { "script": "test-skipped-condition", "skip": ">=0" }
+    ]
+  }
+}
diff --git a/test/test-lookup.js b/test/test-lookup.js
index 3aa0e217..9f7523e7 100644
--- a/test/test-lookup.js
+++ b/test/test-lookup.js
@@ -244,6 +244,79 @@ test('lookup: module in table with scripts', (t) => {
   t.end();
 });
 
+test('lookup: module in table with conditionally skipped scripts', (t) => {
+  t.plan(1);
+  const context = {
+    module: parsePackageArg('omg-i-pass-with-scripts'),
+    meta: createFakeMeta({
+      name: 'omg-i-pass-with-scripts',
+      repository: {
+        url: 'git+https://github.com/nodejs/citgm'
+      }
+    }),
+    options: {
+      lookup: 'test/fixtures/custom-lookup-scripts-skip.json'
+    },
+    emit: function () {}
+  };
+
+  lookup(context);
+  t.strictSame(
+    context.module.scripts,
+    ['test-build', 'test', 'test-not-skipped'],
+    'lookup should omit scripts whose skip condition matches'
+  );
+  t.end();
+});
+
+test('lookup: module in table with invalid scripts entry', (t) => {
+  t.plan(1);
+  const context = {
+    module: parsePackageArg('omg-i-pass-with-scripts'),
+    meta: createFakeMeta({
+      name: 'omg-i-pass-with-scripts',
+      repository: {
+        url: 'git+https://github.com/nodejs/citgm'
+      }
+    }),
+    options: {
+      lookup: 'test/fixtures/custom-lookup-scripts-skip-invalid.json'
+    },
+    emit: function () {}
+  };
+
+  t.throws(
+    () => lookup(context),
+    { name: 'TypeError', message: /must be a string or an object/ },
+    'lookup should throw on a scripts entry without a string script'
+  );
+  t.end();
+});
+
+test('lookup: module in table with every script skipped', (t) => {
+  t.plan(1);
+  const context = {
+    module: parsePackageArg('omg-i-pass-with-scripts'),
+    meta: createFakeMeta({
+      name: 'omg-i-pass-with-scripts',
+      repository: {
+        url: 'git+https://github.com/nodejs/citgm'
+      }
+    }),
+    options: {
+      lookup: 'test/fixtures/custom-lookup-scripts-skip-all.json'
+    },
+    emit: function () {}
+  };
+
+  t.throws(
+    () => lookup(context),
+    /every "scripts" entry is skipped/,
+    'lookup should throw when every script is skipped'
+  );
+  t.end();
+});
+
 test('lookup: module in table with useGitClone', (t) => {
   t.plan(3);
   const context = {